This article is rather technical, but a quotation near the bottom sums it up nicely:

Journal editors have expended much time and effort in teasing out how to handle authors’ and reviewers’ competing interests. They need now to concentrate on their own and those of their employers, lest we reach the dismal scenario described by Marcia Angell: “it is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of The New England Journal of Medicine” [12].

Read the entire article here:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964337/